Partners in Metabolic Health: How cGPMAX® Supports Blood Sugar, Weight, and Energy Balance

When it comes to energy, weight management, and long-term health, your metabolism is at the centre of it all. It governs how you process blood sugar, store fat, and even how much inflammation flows through your body. Two hormones, insulin and insulin-like growth factor-1 (IGF-1), work in close partnership to keep everything running smoothly.

Insulin and IGF-1 are deeply connected. Together they regulate blood sugar, manage fat storage, and maintain overall metabolic health. But when this partnership becomes disrupted by ageing, chronic stress, or conditions such as obesity and type 2 diabetes, it can have serious consequences throughout your body.1–3

The power of IGF-1

Scientists have shown that IGF-1 makes your body more responsive to insulin. It helps glucose move efficiently into your cells while reducing the amount of sugar released by the liver. This creates a more balanced blood sugar response and steadier energy levels.

Low IGF-1 activity can throw this balance off. It is linked with insulin resistance, higher blood sugar, abnormal cholesterol, fat building up around organs, and an increased risk of cardiovascular disease. It also plays a role in inflammation. Since inflammation is a major driver of obesity-related health problems, IGF-1’s natural anti-inflammatory effect is crucial for maintaining metabolic health.

How cGPMAX® works

This is where cGPMAX® comes in. cGPMAX® is a natural supplement that provides cyclic glycine-proline, or cGP, a metabolite of IGF-1 that helps regulate how much IGF-1 is available for your body to use. Think of cGP as a fine tuner that keeps the IGF-1 and insulin system balanced so your metabolism can function at its best.4–6

Dr Jian Guan, Chief Scientist at the cGP Lab and inventor of cGPMAX®, has led groundbreaking research into this molecule. Her studies have revealed the exciting potential of cGP to restore metabolic balance and improve health outcomes.7

In a clinical study with people living with type 2 diabetes and peripheral neuropathy – a common vascular complication of diabetes, supplementation with cGPMAX® brought about clinically meaningful and statistically significant results.8

Supplementation with cGPMAX® led to improved protective foot sensation, reduced HbA1c levels, normalised blood pressure in those with uncontrolled hypertension, improved kidney health, and markers of better vascular integrity. The results show cGPMAX® provides exceptional metabolic and vascular health benefits in those with type 2 diabetes.

Benefits for obesity and metabolic stress

Research in animal studies adds even more support. Supplementing with cGP has been shown to reduce dangerous fat stored around organs, lower high blood pressure, and support IGF-1 activity during times of metabolic stress.9 Since organ fat is strongly linked with insulin resistance, weight gain, and cardiovascular risk, these findings highlight the important role cGPMAX® can play in supporting long-term metabolic health.

Why cGPMAX® matters

What sets cGPMAX® apart is that it works at the foundation of metabolic health. By helping balance IGF-1 activity, it supports healthier blood sugar regulation, fat distribution, cardiovascular function, and inflammation control.

For people concerned about weight loss, blood pressure, or metabolic conditions such as type 2 diabetes, cGPMAX® represents a natural remedy that goes deeper than surface-level symptom management.

Taking control of your health

Your metabolic health is central to your quality of life. Supporting it with the right choices makes a real difference. A balanced diet, regular movement, stress management, and quality sleep form the foundation. Adding cGPMAX® as a supplement can give your body the natural support it needs to restore balance, reduce organ fat, support blood sugar control, and calm inflammation.

Now is the time to take charge of your health and unlock your potential. Click below to find out more about how cGPMAX® can support your journey to better energy, healthier weight, and stronger long-term wellness.

Find out more about cGPMAX® here

References

1. Aguirre, G. A., De Ita, J. R., de la Garza, R. G. & Castilla-Cortazar, I. Insulin-like growth factor-1 deficiency and metabolic syndrome. J. Transl. Med. 14, 3 (2016).
2. Binoux, M. The IGF system in metabolism regulation. Diabete Metab. 21, 330–337 (1995).
3. Kubo, H. et al. Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study. Sci. Rep. 12, 20130 (2022).
4. Guan, J. et al. Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions. Molecules 28, 1021 (2023).
5. Guan, J. et al. The role for cyclic Glycine-Proline, a biological regulator of insulin-like growth factor-1 in pregnancy-related obesity and weight changes. J. Biol. Regul. Homeost. Agents 32, 465–478 (2018).
6. Guan, J. et al. Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1. Sci. Rep. 4, 4388 (2014).
7. Zhu, M. et al. Plasma concentration of cyclic glycine proline is associated with impaired energy metabolism in a Chinese population of type 2 diabetes mellitus. Endocr. Metab. Sci. 17, 100219 (2025).
8. Chen, L. et al. Natural cyclic glycine-proline supplementation improves clinical outcomes of vascular complications in patients with type-2 diabetes mellitus: An exploratory study. J. Funct. Foods 133, 106982 (2025).
9. Li, F. et al. Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. Nutr. Metab. Cardiovasc. Dis. NMCD 30, 339–346 (2020).

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