Dr Jian Guan has studied cGP for over 30 years. She has authored or co-authored over 80 scientific journal articles and her research has been cited in over 2800 scientific papers.

Our Chief Scientist

Our Chief Scientist, Dr Jian Guan is the world authority on cGP. Dr Jian completed a Bachelor of Medicine in China in 1982 and a PhD in Paediatrics at Auckland University, New Zealand in 1996.

During her PhD studies, she specialised in the function and mechanism of insulin-like growth factor-1 (IGF-1). In particular, its role in preventing stroke injuries and promoting stroke recovery.

For the past 25 years, Dr Jian continued her scientific research at Auckland University as a Research Fellow, Senior Research Fellow and Associate Professor affiliated with the Liggins Institute and the Department of Pharmacology and Clinical Pharmacology, at the Faculty of Medical and Health Sciences.

Dr Jian’s research has been largely focused on the discoveries and pharmaceutical developments of IGF-1 and the role of cGP in treating neurological conditions and associated poor brain vessel function, such is found in stroke and age-related cognitive impairments through improving the function of IGF-1.

Ask Our Scientists

If you have any questions for our Chief Scientist Dr Jian Guan or our Scientist Dr Vishshaka Mahajan, they would love to hear from you.

Please e-mail info@cgpmax.com.

Please click here for a list of Dr Guan's scientific papers about cGP..

2021 Gagandeep Singh-Mallah, Maryam Ardalan, Dali Kang, Kuljeet Singh, Christopher D. McMahon, Carina Mallard & Jian Guan, Administration of cyclic glycine proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats, Nutritional Neuroscience, DOI: 10.1080/1028415X.2021.1980845

2021 Singh-Mallah G, Ardalan M, Singh K, Kang D, McMahon C, Mallard C and Guan J.  Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats.Nutritional Neuroscience. August 2021

2021 Kang D, Waldvogel H, Fan D, Wang A, Faull R, Curtis M, Shorten P and Guan J.The autocrine regulation in human brain of Alzheimer’s diseases. Accepted with revision in Psychoneuroendocrinology

2020 Fan D, Pitcher T, Dalrymple-Alford J, MacAskill M, Anderson T and Guan J.Plasma cGP/IGF-1 molar ratio is associated with cognitive status of Parkinson disease.Alzheimer’s Dement. 2020;1–10. 

2019 Li FX, Liu K, Gray C, Harris P, Reynolds C, Vickers M and Guan J.Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. Nutrition, Metabolism & Cardiovascular Diseases. 30: 339-346 

2019 Li FX, Liu K, Wang A, Harris P, Vickers M and Guan J.Cyclic Glycine-Proline Administration Normalizes High-Fat Diet-Induced Synaptic Expressions in Obese Rats. Neuropeptides 76, 101935, 10.1016/j.npep.2019.05.006

2019 Fan D, Krishnamurthi R, Harris P, Barber PA, Guan J.Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients.Annals of Clinical Translational Neurology 2019;0 

2018 Fan D, Alamri Y, Liu K, MacAskill M, Harris P, Brimble M, et al.Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function.Nutrients 2018;10:714. doi:10.3390/nu10060714. 

2018 Alamri Y,The use of dietary supplements and perceived quality of life in patients with Parkinson's disease. J Clin Neuroscience 56: 137-136

2018 GUAN J, SINGH-MALLAH G, LIU K, SHORTEN P, THOMPSON J, MITCHELL E, TAYLOR R, HARRIS P, BRIMBLE M, THORSTENSEN E AND MURPHY R.The role for autocrine regulation of IGF-1 in pregnancy related obesity, a potential biomarker for weight changes. Journal of Biological Regulators and Homeostatic agents 32(3): 11-25 

2017 SINGH-MALLAH G, MCMAHON CD, GUAN J and SINGH KCyclic-glycine-proline promotes post-lactational involution in mammary glands of rats through inhibiting IGF 1 function. Journal of Cellular Physiology 232 (12) 3369-3383doi: 10.1002/jcp.25782 

2016 SINGH-MALLAH G, SINGH K, MCMAHON CD, HARRIS P, BRIMBLE MA and GUAN J,Maternal-infantile transfer following oral administration of cyclic-glycine-proline in lactating rats and its effect on improving memory in the offspringEndocrinology 157(8):3130-9 

2017 YANG P, WALDVOGEL H, Scott E, FAULL R, DRAGUNOW M, TURNER C, AND GUAN J.Endothelial degeneration of Parkinson disease is related to alpha-synuclein aggregation.Journal of Alzheimer’s Disease & Parkinsonism 7: 370. doi: 10.4172/2161-0460.1000370 

2017 YANG P, WALDVOGEL H, FAULL R, DRAGUNOW M, TURNER C, AND GUAN J.Vascular remodelling is impaired in Parkinson’s diseases,Journal of Alzheimer’s Disease & Parkinsonism 7: 313. doi: 10.4172/2161-0460.1000313 

2015 Yang P, Pavlovic D, Richard Faull, Mike Dragunow Beth Synek, Clinton Turner Henry Waldvogel and Guan J,String vessel formation is increased in the brain of Parkinson disease. J of Parkinson Diseases. 5 (2015) 821–8362015

2015 GUAN J, HARRIS P, BRIMBLE M, LEI Y, LU J, YANG Y AND J GUNN A,The role for IGF-1 derived small neuropeptides as a therapeutic target for neurological disorders. Expert Opinion on Therapeutic Targets.Invited review 2015 Feb 5:1-9 

2015 PHILLIPS GMA, SHORTEN PR, WAKE GC AND GUAN J,Dynamical modelling of the effect of insulin-like growth factor -1 on human cell growth.Mathematical Bioscience Journal 2015 Jan; 259:43-54. 

2014 GUAN J, GLUCKMAN PD, YANG PZ, KRISSANSEN G, SUN K, ZHOU Y, WEN JY, SHORTEN P, WAKE G, MCMAHON CD, THOMAS MF, PHILIP G, CHEN W, S MOON, A REN AND LIU DX,Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1Scientific Report, 4, 4388

2014 MATHAI S, GUNN AJ, BRIMBLE MA, HARRIS PW AND GUAN J.Neuroprotection with Glycin-2methyl-Proline-Glutamate (G-2mPE) after hypoxic-ischemic brain injury in adult rats.Journal of Experimental Stroke Translational Medicine 6: 1-112013

2013 GUAN J, MATAI S, LIANG HP AND GUNN JAInsulin-like growth factor-1 and its derivatives: Potential pharmaceutical application for treating neurological conditions. Recent Patents on CNS drug discovery 2013 8(2) 142-168 

2013 Guan J, Pavlovic D, Darkie N, Waldvigel H, Green C and Nicholson L.Vascular degeneration of Parkinson Disease. Brain Pathology 23(2) 154-164 (impact factor 4.7 doi: 10.1111/j.1750-3639.2012628)

2012 MATHAI S, GUNN AJ, BACKHAUS A AND GUAN JWindow of opportunity for neuroprotection with an antioxidant, Allene Oxide Synthase, after hypoxia-ischemia in adult male rats, Journal of Neuroscience and Therapeutics 18(11):887-94 

2012 ZHANG R, KADAR T, SIRIMANNE E, MACGIBBON A AND GUAN JAge-related memory decline in rats is associated with vascular and microglial degeneration,Behavioural Brain Research 1;235(2):210-7 

2010 GUAN J, ZHANG R, L DALE GANDAR AND VICKERS M. NNZ-2591,A novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. Behavioural Brain Research 210, 221-228. 

2009 GUAN J AND GLUCKMAN P.Endogenous small neuropeptides and their analogues: a novel strategy for the development of pharmaceuticals for neurological conditions, invited review by British Journal of Pharmacology 157, 881-891

2009 SHAPIRA S, MATHAI S, ZHANG R AND GUAN JDelayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats.Neuroscience Letter 454 (1) 53-57

2009 KRISHNAMURTHI, R V M., KIM A H., MATHAI S. RONG ZHANG AND GUAN J.Delayed treatment with a novel diketopiperazine improves motor function after 6-OHDA lesion in rats. British Journal of Pharmacology 156, 662-672.

2008 JACOBSON L, ZHANG R, ELLIFFE D, CHEN C, MATHAI S, MCCARTHY D, WALDVOGE H AND GUAN J.Co-relation of cellular/vascular changes and spatial memory during aging in ratsExperimental Gerontology 43, 928-938

2007 GUAN J, MATHAI S, HARRIS P, BRIMBLE M, WEN JY ZHANG R and GLUCKMAN PPeripheral administration of a novel diketopiperazine, NNZ 2591 prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats.Neuropharmacolocy 53: 749-762 

2007 SVEDIN P, GUAN J*(co-responding author), MATHAI S, ZHANG R, WANG XY, HAGBERG H AND MALLARD CDelayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat. Developmental neuroscience 29: 393-402 

2005 BAKER A M, BATCHELOR D C, THOMAS G B, CLARK R G, RAFIEE M, LIN H AND GUAN JCentral penetration and the stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat.Neuropeptides 39(2) 81-87

2004 GUAN J, THOMAS G B, LIN H, MATAI S, BACHELOR D C, GEORGE S, FERNANDEZ J AND GLUCKMAN PDNeuroprotective effects of the N-terminal tripeptide of insulin-like growth factor –1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats.Neuropharmacology Vol 47 (6): 892-903

2004 KRISHNAMURTHI R, STOTT S, MAINGAY M, FAULL RLM, MCCARTHY D, GLUCKMAN PD AND GUAN J.N-terminal tripeptide of insulin-like growth factor –1 (GPE) improves functional deficits after 6-OHDA lesion in rats.NeuroReport 15(10); 1601-1604 

2003 GUAN J, BENNET L PD GLUCKMAN AND GUNN AJ,Insulin-like growth factor-1 and the ischemic brain. Progress in Neurology 70 (6), 443-462 

2000 GUAN J., KRISHNAMURTHI, R., WALDVOGEL, H.J., FAULL, R.L.M., CLARK, R. AND GLUCKMAN, P.N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats. Brain Research 859 (2) 286-292,

1999, GUAN J, WALDVOGEL H, FAULL R, GLUCKMAN P AND WILLIAMS CThe effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats.Neuroscience 89: 649-659