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Medical researchers and scientists have for many years been researching ways in which to synthetically increase the IGF-1 hormone  (insulin-like growth factor 1) .

The IGF-1 hormone is responsible for promoting the growth of new cells and capillaries. This is especially important as the body ages. The IGF-1 cannot be directly or artificially increased by supplementation.

Then our Chief Scientist, Dr Jian Guan made a world first discovery. She discovered that a molecule called cGP (cyclic Glycine-Proline) was responsible for controlling the IGF-1 hormone in our body. Thus by increasing the level of cGP in our body, the cGP will essentially command the IGF-I to build more blood vessels.

Dr Jian Guan, was then recognised as the world-wide authority on cGP. In 2017 she discovered that NZ blackcurrants contained high volumes of natural cGP which when taken would regulate optimum levels of IGF-1 in the body. 

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Dr Jian’s clinical scientific research studies validated the levels of cGP the human body needs. Trials were then undertaken to establish how our product cGPMAX™ could deliver enough natural cGP to the body to lift and maintain IGF-1 levels in the human body. 

The culmination of the research has led The cGP Lab to develop our hero ingredient called cGPMAX™.

The cGP Lab has developed products that confidently and consistently deliver the recommended daily dose of natural cGP from New Zealand blackcurrants.

The cGP Lab are now utilising this knowledge to further research the testing and commercialisation of other sources of natural cGP and the effects of supplementation of cGPMAX™ on various health conditions, including metabolic syndromes.

The Impact of cGP on Neurological Conditions

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Memory Loss Caused by Poor Circulation in Ageing Brains

A healthy brain constantly produces new blood vessels to replace the loss of capillaries (small blood vessels). The body’s ability to make new blood vessels diminishes with age [17]. As a result, the capillary nets that deliver oxygen and nutrients to brain cells are getting fewer and fewer with age. Undernourished brain cells do not work and the build-up of toxins can kill the brain cells slowly causing brain degeneration.

The function of cGP is to encourage the cells in the brain to make new blood vessels [1, 4] and taking a daily dose of our cGPMAX™ supplement allows the body to produce more blood vessels, increasing blood circulation in the brain. A study shows that older healthy people with higher levels of cGP in their blood circulation show better memory and other cognitive function [6]. Gradually increasing the level of cGP in the blood as the body ages is the key to keeping cognitive function normal whereas people with dementia show a gradual decreasing of cGP as they age [6]. 

Increasing cGP levels through supplementation or intervention, such as cGPMAX™ may help older people retain their memory and slow down the progress of memory decline and preventing dementia.

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Brain Degeneration in Parkinson’s Disease

The body’s ability to make new blood vessels is also impaired in the brains of people suffering from Parkinson’s [18], partially due to their impaired IGF-1 function [19].

The function of IGF-1 becomes impaired due to high levels of the IGF binding protein (IGFBP)-2, as was present in the brains of people suffering from Parkinson’s [19]. The IGFBP-2 acts as a locker to prevent IGF-1 from being functional. As a result , more IGFBP-2 impairs the IGF-1 function. Taking additional cGP via a cGP supplement can unlock the IGF-1 from the IGFBP-2, resulting in improved IGF-1 function, thus helping the brain to produce more blood vessels, thus improving brain function.

We conducted a small clinical trial to test whether increasing cGP through supplementing cGPMAX will lead to any improvement in PD patients [11, 12]. Four weeks supplementation of cGPMAX (previously known as Brain shield) increases the level of in the blood and brain with a positive result of reduced anxiety and degression [11, 12].

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Alzheimer’s Disease

Poor vascular function and changes to the IGF-1 function in human brains is known to contribute to dementia in people with Alzheimer’s.

The IGF-1 function is determined by amount of protein and amount of IGF-1 that has been unlocked by cGP [20]. Compared to the non- Alzheimer’s cases, the IGF-1 function is significantly impaired which contributes to brain degeneration typical of people suffering from Alzheimer’s [20]. As found in the brains of Parkinson’s diseases, IGFBP-3 is increased in the brain of Alzheimer’s diseases, which locks in IGF-1 and further impairs IGF-1 function [20]. 

The amount of cGP that acts to unlock IGF-1 from IGFBP-3 is also increases. This self-made defence, however, is not sufficient to stop brain degeneration. The supplementation of cGPMAX™ into the brain may also help an Alzheimer’s brain to strength the IGF-1 function by unlocking more IGF-1 from IGFBPs.

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Ischemic Attack, Commonly Known as a Stroke

A stoke occurs when the blood supply to a part of the brain is suddenly disrupted.

Within 3 days after a stroke event, the patient’s level of cGP is low compared to non-stroke participants [7]. However, their cGP level gradually increases during the first 3 months following the stroke, while patients make a steady recovery [7]. The study found that 3 months after a stoke, patients with higher levels of cGP at the time of their stroke made a better recovery [7]. The body’s  self-made recovery plateaus after 3 months. The patients may make a better, faster and longer-term recovery if the cGP level increases through an intervention at the time of stroke.

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Metabolic Disorders

High blood pressure is the result of poor circulation and reduced vascular function. The most common cause of high blood pressure is aging and metabolic disorders.

People with metabolic disorders especially high blood pressure have a low level of cGP [10] and have higher chance of having a stroke, cognitive impairment and premature brain aging. Increasing levels of cGP through supplementation may normalise blood pressure and reduce organ fat, thereby improving blood vessel function and overall circulation.

In summary, IGF-1 function starts to decline at around 45 years of age. In response, the body’s demand for cGP increases to maintain normal IGF-1 function. The body’s self-made protection by producing more cGP may not be sufficient to maintain health. When body starts to lose the ability to make cGP, cGP levels will decline, as seen in people with hypertension, stroke or dementia [6-8].

To counteract this, increasing cGP in your body by supplementing with cGPMAX will help to maintain your health. Dr Jian’s research has shown that maintaining high levels of cGP helps to keep your mind and body healthier as you age.

Scientific Papers Referenced Above